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USC-OGP 2-DE database
Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database
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Searching in 'USC-OGP 2-DE database' for entry
matching:
KAP2_HUMAN
USC-OGP 2-DE database
:
KAP2_HUMAN
KAP2_HUMAN
General information about the entry
View entry in simple text format
Entry name
KAP2_HUMAN
Primary accession number
P13861
integrated into USC-OGP 2-DE database on
January 17, 2017 (release 1)
2D Annotations were last modified on
January 17, 2017 (version 1)
General Annotations were last modified on
April 5, 2017 (version 2)
Name and origin of the protein
Description
RecName: Full=cAMP-dependent protein kinase type II-alpha regulatory subunit;.
Gene name
Name=PRKAR2A
Synonyms=PKR2, PRKAR2
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein
PLATELET_4-5
{PLATELET 4-5}
Homo sapiens (Human)
map experimental info
PLATELET_4-5
MAP LOCATIONS:
SPOT OGP-0075
:
pI=4.90; Mw=50169
Cross-references
UniProtKB/Swiss-Prot
P13861; KAP2_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
0.0
Entry name
KAP2_HUMAN
Primary accession number
P13861
Secondary accession number(s)
Q16823 Q9BUB1
Sequence was last modified on
January 23, 2007 (version 2)
Annotations were last modified on
March 15, 2017 (version 179)
Name and origin of the protein
Description
RecName: Full=cAMP-dependent protein kinase type II-alpha regulatory subunit;
Gene name
Name=PRKAR2A
Synonyms=PKR2, PRKAR2
Encoded on
Name=PRKAR2A; Synonyms=PKR2, PRKAR2
Keywords
3D-structure
;
Acetylation
;
Alternative splicing
;
cAMP
;
cAMP-binding
;
Cell membrane
;
Complete proteome
;
Cytoplasm
;
Membrane
;
Nucleotide-binding
;
Phosphoprotein
;
Reference proteome
;
Repeat
.
Copyright
Copyrighted by the UniProt Consortium, see
http://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
X14968; CAA33094.1
; -; mRNA
EMBL
BT007225; AAP35889.1
; -; mRNA
EMBL
AC141002; -
; NOT_ANNOTATED_CDS; Genomic_DNA
EMBL
AC144546; -
; NOT_ANNOTATED_CDS; Genomic_DNA
EMBL
CH471055; EAW64926.1
; -; Genomic_DNA
EMBL
CH471055; EAW64927.1
; -; Genomic_DNA
EMBL
BC002763; AAH02763.1
; -; mRNA
EMBL
X99455; CAA67817.1
; -; Genomic_DNA
CCDS
CCDS2778.1; -. [P13861-1]
; .
CCDS
CCDS82771.1; -. [P13861-2]
; .
PIR
S03885; OKHU2R
; .
RefSeq
NP_001308911.1; NM_001321982.1. [P13861-1]
; .
RefSeq
NP_001308912.1; NM_001321983.1. [P13861-2]
; .
RefSeq
NP_004148.1; NM_004157.3. [P13861-1]
; .
RefSeq
XP_011532244.1; XM_011533942.2. [P13861-1]
; .
RefSeq
XP_016862304.1; XM_017006815.1. [P13861-1]
; .
UniGene
Hs.631923; -
; .
UniGene
Hs.731573; -
; .
PDB
2IZX; X-ray
; 1.30 A; A/B=4-44
PDB
2KYG; NMR
; -; A/B=1-45
PDB
4ZP3; X-ray
; 2.63 A; A/B/C/D/E/F/G/H/I/J/K/L=2-44
PDBsum
2IZX; -
; .
PDBsum
2KYG; -
; .
PDBsum
4ZP3; -
; .
ProteinModelPortal
P13861; -
; .
SMR
P13861; -
; .
BioGrid
111562; 67
; .
DIP
DIP-552N; -
; .
IntAct
P13861; 58
; .
MINT
MINT-5000495; -
; .
STRING
9606.ENSP00000265563; -
; .
DrugBank
DB05798; GEM-231
; .
GuidetoPHARMACOLOGY
1474; -
; .
iPTMnet
P13861; -
; .
PhosphoSitePlus
P13861; -
; .
BioMuta
PRKAR2A; -
; .
DMDM
125198; -
; .
OGP
P13861; -
; .
EPD
P13861; -
; .
MaxQB
P13861; -
; .
PaxDb
P13861; -
; .
PeptideAtlas
P13861; -
; .
PRIDE
P13861; -
; .
DNASU
5576; -
; .
Ensembl
ENST00000265563; ENSP00000265563
; ENSG00000114302. [P13861-1]; .
Ensembl
ENST00000296446; ENSP00000296446
; ENSG00000114302. [P13861-2]; .
Ensembl
ENST00000454963; ENSP00000394041
; ENSG00000114302. [P13861-1]; .
GeneID
5576; -
; .
KEGG
hsa:5576; -
; .
UCSC
uc003cux.2; human. [P13861-1]
; .
CTD
5576; -
; .
DisGeNET
5576; -
; .
GeneCards
PRKAR2A; -
; .
HGNC
HGNC:9391; PRKAR2A
; .
HPA
CAB005023; -
; .
HPA
HPA038268; -
; .
MalaCards
PRKAR2A; -
; .
MIM
176910; gene
; .
neXtProt
NX_P13861; -
; .
OpenTargets
ENSG00000114302; -
; .
PharmGKB
PA33757; -
; .
eggNOG
KOG1113; Eukaryota
; .
eggNOG
COG0664; LUCA
; .
GeneTree
ENSGT00530000062947; -
; .
HOGENOM
HOG000196668; -
; .
HOVERGEN
HBG002025; -
; .
InParanoid
P13861; -
; .
KO
K04739; -
; .
OMA
MSERMKI; -
; .
OrthoDB
EOG091G0F1K; -
; .
PhylomeDB
P13861; -
; .
TreeFam
TF314920; -
; .
Reactome
R-HSA-163615; PKA activation
; .
Reactome
R-HSA-164378; PKA activation in glucagon signalling
; .
Reactome
R-HSA-180024; DARPP-32 events
; .
Reactome
R-HSA-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
; .
Reactome
R-HSA-432040; Vasopressin regulates renal water homeostasis via Aquaporins
; .
Reactome
R-HSA-5610787; Hedgehog 'off' state
; .
Reactome
R-HSA-983231; Factors involved in megakaryocyte development and platelet production
; .
SignaLink
P13861; -
; .
SIGNOR
P13861; -
; .
ChiTaRS
PRKAR2A; human
; .
EvolutionaryTrace
P13861; -
; .
GeneWiki
PRKAR2A; -
; .
GenomeRNAi
5576; -
; .
PRO
PR:P13861; -
; .
Proteomes
UP000005640; Chromosome 3
; .
Bgee
ENSG00000114302; -
; .
CleanEx
HS_PRKAR2A; -
; .
ExpressionAtlas
P13861; baseline and differential
; .
Genevisible
P13861; HS
; .
GO
GO:0005952; C:cAMP-dependent protein kinase complex
; IEA:InterPro; .
GO
GO:0005813; C:centrosome
; IDA:UniProtKB; .
GO
GO:0097546; C:ciliary base
; TAS:Reactome; .
GO
GO:0005737; C:cytoplasm
; IDA:UniProtKB; .
GO
GO:0005829; C:cytosol
; TAS:Reactome; .
GO
GO:0070062; C:extracellular exosome
; IDA:UniProtKB; .
GO
GO:0005925; C:focal adhesion
; IDA:UniProtKB; .
GO
GO:0016020; C:membrane
; IDA:UniProtKB; .
GO
GO:0031588; C:nucleotide-activated protein kinase complex
; IDA:BHF-UCL; .
GO
GO:0005886; C:plasma membrane
; IDA:UniProtKB; .
GO
GO:0044853; C:plasma membrane raft
; IDA:UniProtKB; .
GO
GO:0030552; F:cAMP binding
; IEA:UniProtKB-KW; .
GO
GO:0004862; F:cAMP-dependent protein kinase inhibitor activity
; IDA:BHF-UCL; .
GO
GO:0008603; F:cAMP-dependent protein kinase regulator activity
; NAS:UniProtKB; .
GO
GO:0034236; F:protein kinase A catalytic subunit binding
; IPI:UniProtKB; .
GO
GO:0031625; F:ubiquitin protein ligase binding
; IDA:UniProtKB; .
GO
GO:0034199; P:activation of protein kinase A activity
; TAS:Reactome; .
GO
GO:0007596; P:blood coagulation
; TAS:Reactome; .
GO
GO:0071377; P:cellular response to glucagon stimulus
; TAS:Reactome; .
GO
GO:0035556; P:intracellular signal transduction
; TAS:ProtInc; .
GO
GO:2000480; P:negative regulation of cAMP-dependent protein kinase activity
; IDA:BHF-UCL; .
GO
GO:0003091; P:renal water homeostasis
; TAS:Reactome; .
Gene3D
1.20.890.10; -
; 1; .
Gene3D
2.60.120.10; -
; 2; .
InterPro
IPR012198; cAMP_dep_PK_reg_su
; .
InterPro
IPR003117; cAMP_dep_PK_reg_su_I/II_a/b
; .
InterPro
IPR018490; cNMP-bd-like
; .
InterPro
IPR018488; cNMP-bd_CS
; .
InterPro
IPR000595; cNMP-bd_dom
; .
InterPro
IPR014710; RmlC-like_jellyroll
; .
Pfam
PF00027; cNMP_binding
; 2; .
Pfam
PF02197; RIIa
; 1; .
PIRSF
PIRSF000548; PK_regulatory
; 1; .
SMART
SM00100; cNMP
; 2; .
SMART
SM00394; RIIa
; 1; .
SUPFAM
SSF47391; SSF47391
; 1; .
SUPFAM
SSF51206; SSF51206
; 2; .
PROSITE
PS00888; CNMP_BINDING_1
; 2; .
PROSITE
PS00889; CNMP_BINDING_2
; 2; .
PROSITE
PS50042; CNMP_BINDING_3
; 2; .
Gateways to other related servers
The World-2DPAGE Constellation
- Entry point to the world-wide 2-DPAGE resources.
World-2DPAGE Repository
- A public repository for gel-based proteomics data linked to protein identification published in the literature.
World-2DPAGE Portal
- A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
SWISS-2DPAGE
- The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
ExPASy
- The resources web server of the
Swiss Institute of Bioinformatics
Database constructed and maintained by
Angel Garcia
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server
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