Home

USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database


USC-OGP 2-DE database 
Search by   *
 
 
 
 
 
 
Maps   
 
 


     Select Remote Interfaces
[All Interfaces]
SWISS-2DPAGE
World-2DPAGE Portal
World-2DPAGE Repository

Exclude local DBs
has only effect if a remote
interface is selected
     
Searching in 'USC-OGP 2-DE database' for entry matching: KAP2_HUMAN




USC-OGP 2-DE database:  KAP2_HUMAN


KAP2_HUMAN


General information about the entry
View entry in simple text format
Entry nameKAP2_HUMAN
Primary accession numberP13861
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=cAMP-dependent protein kinase type II-alpha regulatory subunit;.
Gene nameName=PRKAR2A
Synonyms=PKR2, PRKAR2
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

PLATELET_4-5 {PLATELET 4-5}
Homo sapiens (Human)
PLATELET_4-5
  map experimental info
 
PLATELET_4-5

MAP LOCATIONS:
pI=4.90; Mw=50169

Cross-references
UniProtKB/Swiss-ProtP13861; KAP2_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameKAP2_HUMAN
Primary accession numberP13861
Secondary accession number(s) Q16823 Q9BUB1
Sequence was last modified on January 23, 2007 (version 2)
Annotations were last modified on March 15, 2017 (version 179)
Name and origin of the protein
DescriptionRecName: Full=cAMP-dependent protein kinase type II-alpha regulatory subunit;
Gene nameName=PRKAR2A
Synonyms=PKR2, PRKAR2
Encoded onName=PRKAR2A; Synonyms=PKR2, PRKAR2
Keywords3D-structure; Acetylation; Alternative splicing; cAMP; cAMP-binding; Cell membrane; Complete proteome; Cytoplasm; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX14968; CAA33094.1; -; mRNA
EMBLBT007225; AAP35889.1; -; mRNA
EMBLAC141002; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLAC144546; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLCH471055; EAW64926.1; -; Genomic_DNA
EMBLCH471055; EAW64927.1; -; Genomic_DNA
EMBLBC002763; AAH02763.1; -; mRNA
EMBLX99455; CAA67817.1; -; Genomic_DNA
CCDSCCDS2778.1; -. [P13861-1]; .
CCDSCCDS82771.1; -. [P13861-2]; .
PIRS03885; OKHU2R; .
RefSeqNP_001308911.1; NM_001321982.1. [P13861-1]; .
RefSeqNP_001308912.1; NM_001321983.1. [P13861-2]; .
RefSeqNP_004148.1; NM_004157.3. [P13861-1]; .
RefSeqXP_011532244.1; XM_011533942.2. [P13861-1]; .
RefSeqXP_016862304.1; XM_017006815.1. [P13861-1]; .
UniGeneHs.631923; -; .
UniGeneHs.731573; -; .
PDB2IZX; X-ray; 1.30 A; A/B=4-44
PDB2KYG; NMR; -; A/B=1-45
PDB4ZP3; X-ray; 2.63 A; A/B/C/D/E/F/G/H/I/J/K/L=2-44
PDBsum2IZX; -; .
PDBsum2KYG; -; .
PDBsum4ZP3; -; .
ProteinModelPortalP13861; -; .
SMRP13861; -; .
BioGrid111562; 67; .
DIPDIP-552N; -; .
IntActP13861; 58; .
MINTMINT-5000495; -; .
STRING9606.ENSP00000265563; -; .
DrugBankDB05798; GEM-231; .
GuidetoPHARMACOLOGY1474; -; .
iPTMnetP13861; -; .
PhosphoSitePlusP13861; -; .
BioMutaPRKAR2A; -; .
DMDM125198; -; .
OGPP13861; -; .
EPDP13861; -; .
MaxQBP13861; -; .
PaxDbP13861; -; .
PeptideAtlasP13861; -; .
PRIDEP13861; -; .
DNASU5576; -; .
EnsemblENST00000265563; ENSP00000265563; ENSG00000114302. [P13861-1]; .
EnsemblENST00000296446; ENSP00000296446; ENSG00000114302. [P13861-2]; .
EnsemblENST00000454963; ENSP00000394041; ENSG00000114302. [P13861-1]; .
GeneID5576; -; .
KEGGhsa:5576; -; .
UCSCuc003cux.2; human. [P13861-1]; .
CTD5576; -; .
DisGeNET5576; -; .
GeneCardsPRKAR2A; -; .
HGNCHGNC:9391; PRKAR2A; .
HPACAB005023; -; .
HPAHPA038268; -; .
MalaCardsPRKAR2A; -; .
MIM176910; gene; .
neXtProtNX_P13861; -; .
OpenTargetsENSG00000114302; -; .
PharmGKBPA33757; -; .
eggNOGKOG1113; Eukaryota; .
eggNOGCOG0664; LUCA; .
GeneTreeENSGT00530000062947; -; .
HOGENOMHOG000196668; -; .
HOVERGENHBG002025; -; .
InParanoidP13861; -; .
KOK04739; -; .
OMAMSERMKI; -; .
OrthoDBEOG091G0F1K; -; .
PhylomeDBP13861; -; .
TreeFamTF314920; -; .
ReactomeR-HSA-163615; PKA activation; .
ReactomeR-HSA-164378; PKA activation in glucagon signalling; .
ReactomeR-HSA-180024; DARPP-32 events; .
ReactomeR-HSA-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; .
ReactomeR-HSA-432040; Vasopressin regulates renal water homeostasis via Aquaporins; .
ReactomeR-HSA-5610787; Hedgehog 'off' state; .
ReactomeR-HSA-983231; Factors involved in megakaryocyte development and platelet production; .
SignaLinkP13861; -; .
SIGNORP13861; -; .
ChiTaRSPRKAR2A; human; .
EvolutionaryTraceP13861; -; .
GeneWikiPRKAR2A; -; .
GenomeRNAi5576; -; .
PROPR:P13861; -; .
ProteomesUP000005640; Chromosome 3; .
BgeeENSG00000114302; -; .
CleanExHS_PRKAR2A; -; .
ExpressionAtlasP13861; baseline and differential; .
GenevisibleP13861; HS; .
GOGO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro; .
GOGO:0005813; C:centrosome; IDA:UniProtKB; .
GOGO:0097546; C:ciliary base; TAS:Reactome; .
GOGO:0005737; C:cytoplasm; IDA:UniProtKB; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0005925; C:focal adhesion; IDA:UniProtKB; .
GOGO:0016020; C:membrane; IDA:UniProtKB; .
GOGO:0031588; C:nucleotide-activated protein kinase complex; IDA:BHF-UCL; .
GOGO:0005886; C:plasma membrane; IDA:UniProtKB; .
GOGO:0044853; C:plasma membrane raft; IDA:UniProtKB; .
GOGO:0030552; F:cAMP binding; IEA:UniProtKB-KW; .
GOGO:0004862; F:cAMP-dependent protein kinase inhibitor activity; IDA:BHF-UCL; .
GOGO:0008603; F:cAMP-dependent protein kinase regulator activity; NAS:UniProtKB; .
GOGO:0034236; F:protein kinase A catalytic subunit binding; IPI:UniProtKB; .
GOGO:0031625; F:ubiquitin protein ligase binding; IDA:UniProtKB; .
GOGO:0034199; P:activation of protein kinase A activity; TAS:Reactome; .
GOGO:0007596; P:blood coagulation; TAS:Reactome; .
GOGO:0071377; P:cellular response to glucagon stimulus; TAS:Reactome; .
GOGO:0035556; P:intracellular signal transduction; TAS:ProtInc; .
GOGO:2000480; P:negative regulation of cAMP-dependent protein kinase activity; IDA:BHF-UCL; .
GOGO:0003091; P:renal water homeostasis; TAS:Reactome; .
Gene3D1.20.890.10; -; 1; .
Gene3D2.60.120.10; -; 2; .
InterProIPR012198; cAMP_dep_PK_reg_su; .
InterProIPR003117; cAMP_dep_PK_reg_su_I/II_a/b; .
InterProIPR018490; cNMP-bd-like; .
InterProIPR018488; cNMP-bd_CS; .
InterProIPR000595; cNMP-bd_dom; .
InterProIPR014710; RmlC-like_jellyroll; .
PfamPF00027; cNMP_binding; 2; .
PfamPF02197; RIIa; 1; .
PIRSFPIRSF000548; PK_regulatory; 1; .
SMARTSM00100; cNMP; 2; .
SMARTSM00394; RIIa; 1; .
SUPFAMSSF47391; SSF47391; 1; .
SUPFAMSSF51206; SSF51206; 2; .
PROSITEPS00888; CNMP_BINDING_1; 2; .
PROSITEPS00889; CNMP_BINDING_2; 2; .
PROSITEPS50042; CNMP_BINDING_3; 2; .



USC-OGP 2-DE database image


Gateways to other related servers


Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

[Home]